Does inhibition of aldose reductase contribute to the anti-inflammatory action of setipiprant ?

Title:

Does inhibition of aldose reductase contribute to the anti-inflammatory action of setipiprant ?

Creator:

Ballekova, J., Soltesova-Prnova, M., Magdaléna Májeková, and Stefek, M.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:12ffa24c-fcde-4791-a0f8-97548e8c5a95
uuid:12ffa24c-fcde-4791-a0f8-97548e8c5a95
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, astma, záněty, asthma, inflammations, setipiprant, aldose reductase inhibition, androgenic alopecia, 14, and 612

Type:

article, články, journal articles, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

The aim of this study was to investigate aldose reductase inhibitory action of setipiprant as a potential additional mechanism contributing to its anti-inflammatory action. Aldose reductase activity was determined by spectrophotometric measuring of NADPH consumption. Setipiprant was found to inhibit aldose reductase/NADPH-mediated reduction of 4-hydroxynonenal, 4-hydroxynonenal glutathione and prostaglandin H2 substrates, all relevant to the process of inflammation. Molecular modeling simulations into the aldose reductase inhibitor binding site revealed an interaction pattern of setipiprant. Considering multifactorial etiology of inflammatory pathologies, it is suggested that, in addition to the antagonizing prostaglandin D2 receptor, inhibition of aldose reductase may contribute to the reported anti-inflammatory action of setipiprant., J. Ballekova, M. Soltesova-Prnova, M. Majekova, M. Stefek., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2017 Volume:66 | Number:4

Harvested from:

CDK

Metadata only:

false