Mechanism of action of homocysteine and its thiolactone in hemostasis system

Title:

Mechanism of action of homocysteine and its thiolactone in hemostasis system

Creator:

Karolczak, K. and Olas, B.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:1348325f-7de1-4a40-8d07-6f1d02268bc2
uuid:1348325f-7de1-4a40-8d07-6f1d02268bc2

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie, homocystein, hemostáza, human physiology, homocysteine, hemostasis, homocystein thiolakton, homocysteine thiolactone, 14, and 612

Type:

article, články, model:article, and TEXT

Description:

In the article, the actions of homocysteine (Hcys) and its metabolite - cyclic thioester – homocysteine thiolactone (HTL) on complex process of hemostasis, which regulates the flowing properties of blood, are described. Possible interaction of Hcys and HTL with endothelial cells, blood platelets, plasmatic fibrinogen and plasminogen, as the important major components of hemostasis are also discussed. The modification of hemostatic proteins (N-homocysteinylated or S-homocysteinylated proteins) induced by Hcys or its thiolactone, and links of homocysteine or homocysteine thiolactone to •NO metabolism seem to be the main reason of biotoxicty of homocysteine in cardiovascular diseases., K. Karolczak, B. Olas., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2009 Volume:58 | Number:5

Harvested from:

CDK

Metadata only:

false