Acquisition and retrieval of conditioned taste aversion is impaired by brain damage caused by two hours of pilocarpine - induced status epilepticus

Title:

Acquisition and retrieval of conditioned taste aversion is impaired by brain damage caused by two hours of pilocarpine - induced status epilepticus

Creator:

Šroubek, J., Jakub Hort, Vladimír Komárek, Miloš Langmeier, and Gustav Brožek

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:143f1eb6-0c0e-4562-aa62-06cdd469c182
uuid:143f1eb6-0c0e-4562-aa62-06cdd469c182
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, epilepsie, epilepsy, conditioned taste aversion, pilocarpine, nondeclarative memory, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

The effect of Cavalheiro's pilocarpine model of epileptogenesis upon conditioned taste aversion (CTA), an important example of nondeclarative memory, was studied in adult Long Evans rats. Deterioration of CTA was studied during the silent period between pilocarpine-induced status epilepticus (SE) and delayed spontaneous recurrent seizures. SE was elicited by i.p. injection of pilocarpine (320 mg/kg ) and interrupted after 2 hours by clonazepame (1 mg/kg i.p.). Peripheral cholinergic symptoms were suppressed by methylscopolamine (1 mg/kg i.p.), administered together with pilocarpine. CTA was formed against the salty taste of isotonic LiCl. In the experiment of CTA acquisition, the CTA was formed and tested during the silent period after SE. In the experiment of CTA retrieval, the CTA was acquired before SE and the retrieval itself was tested during the silent period. Retrieval of CTA acquired before SE was impaired more than the retrieval of CTA formed during the silent period. Our findings indicate that epileptic seizures can disrupt even non-declarative memory but that CTA formed by the damaged brain can use its better preserved parts for memory trace formation. Ketamine (50 mg/kg i.p.) applied 2 min after the onset of pilocarpine-induced status epilepticus protected memory deterioration., J. Šroubek, J. Hort, V. Komárek, M. Langmeier, G. Brožek., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2001 Volume:50 | Number:6

Harvested from:

CDK

Metadata only:

false