Allelic and Haplotype Frequencies of the p53 Polymorphisms in Brain Tumor Patients

Title:

Allelic and Haplotype Frequencies of the p53 Polymorphisms in Brain Tumor Patients

Creator:

Erik Biroš, Ivan Kalina, Anton Kohút, Bogyiová, E., Šalagovič, J., and Igor Šulla

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:15db6d0f-124d-4f69-b2f0-d37dc1b94658
uuid:15db6d0f-124d-4f69-b2f0-d37dc1b94658
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, Brain tumor, Susceptibility, p53, Polymorphism, 14, and 612

Type:

article, studie, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

The polymorphisms of the tumor suppressor gene p53 in exon 4 (p53 BstUI) and in intron 6 (p53 MspI) have been suggested to be associated with the genetically determined susceptibility in diverse types of human cancer. In our hospital-based case-control study, we examined the allele and genotype incidence of these polymorphisms as well as their haplotype combinations in 60 brain tumor patients (27 males and 33 females) and 183 controls without malignancies. The genotype characteristics were determined by the PCR-based RFLP method using DNA extracted from peripheral blood. In this study we show that the p53 BstUI and the p53 MspI polymorphisms are not associated with increased risk of brain tumors. Thus, we conclude that the p53 BstUI and the p53 MspI polymorphic sites within the tumor suppressor gene p53 do not represent genetic determinants of susceptibility to brain tumors., E. Biroš, I. Kalina, A. Kohút, E. Bogyiová, J. Šalagovič, I. Šulla., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2002 Volume:51 | Number:1

Harvested from:

CDK

Metadata only:

false