Mathematical model of the electromechanical heart contractile system - regulatory subsystem physiological considerations

Title:

Mathematical model of the electromechanical heart contractile system - regulatory subsystem physiological considerations

Creator:

Mikuláš Mlček, Neumann, J., Otomar Kittnar, and Novák, V.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:164ff07f-a54e-48ff-80ef-fcffcf6b6f1c
uuid:164ff07f-a54e-48ff-80ef-fcffcf6b6f1c
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie, physiology, myocardial contraction, excitation-contraction coupling, simulations, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

The biochemical model of excitation-contraction coupling in cardiomyocyte is presented and the validity of simulations of both physiological and pathological processes is discussed. The model of regulatory and actomyosin subsystems, even if it is rather simple in its regulatory subunit, gives results well consistent with experimental data. Specifically, intracellular free calcium levels ([Ca2+]i) were computed under various states of sarcoendoplasmic reticular Ca2+-ATPase (SERCA2) and compared to experimental findings. Computed results reproduced well both the increase in resting [Ca2+]i level and the attenuation of [Ca2+]i decline commonly observed in heart failure. Thus the computational simulations could help to identify core relations in studied systems by comparing results obtained using similar models of various complexities., M. Mlček, J. Neumann, O. Kittnar, V. Novák., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2001 Volume:50 | Number:4

Harvested from:

CDK

Metadata only:

false