Effect of repeated infestations of BALB/c mice with Ixodes ricinus nymphs on tick-borne encephalitis virus infection

Title:

Effect of repeated infestations of BALB/c mice with Ixodes ricinus nymphs on tick-borne encephalitis virus infection

Creator:

Dusbábek, F., Kopecký, J., and Uhlíř, J.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:17b57d3e-0b58-4215-8c19-8b543d4ea653
uuid:17b57d3e-0b58-4215-8c19-8b543d4ea653
urnnbn:urn:nbn:cz:aba007-000dix

Subject:

Tick-borne encephalitis virus, virus transmission, Ixodes ricinus nymphs, and immunosuppression

Type:

model:internalpart and TEXT

Format:

print

Description:

The effect of repeated infestations of BALB/c mice with Ixodes ricinus (L.) nymphs on tick borne encephalitis (TBE) virus infection was studied. Enhancement of nymphal feeding, occurring in noninfected mice during the quaternary infestations, was less apparent or absent in female nymphs engorged on TBE virus infected mice. The mice infected with TBE virus during quaternary tick infestation survived significantly longer (P < 0.01) than mice infected with TBE virus during the primary tick infestation. The mean titre of virus in murine blood (determined by plaque assay) was significantly lower (P < 0.01) and the number of nymphs acquiring virus was reduced (P < 0.05) when feeding on hosts infected during the quaternary infestation. The results indicate that repeated infestations of I. ricinus nymphs on BALB/c mice, although enhancing tick feeding, reduced infection with TBE virus when inoculated intraperitoneally.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Coverage:

312-316 and 74-78

Source:

Folia parasitologica | 1994 Volume:41 | Number:4

Harvested from:

CDK

Metadata only:

false