Circulating levels of WISP-1 (Wnt1-inducible signaling pathway protein 1) and other selected adipokines in children with inflammatory bowel disease

Title:

Circulating levels of WISP-1 (Wnt1-inducible signaling pathway protein 1) and other selected adipokines in children with inflammatory bowel disease

Creator:

Karasková, Eva, Kubickova, Veronika, Velganova-Veghova, Maria, Geryk, Milos, Foltenova, Hana, and Karasek, David

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:1860d7c9-dfe4-4600-841c-efc793084da8
uuid:1860d7c9-dfe4-4600-841c-efc793084da8
doi:10.33549/physiolres.934854

Subject:

inflammatory bowel disease, Wnt1 inducible signaling pathway protein-1, adiponectin, resistin, and retinol-binding protein 4

Type:

model:article and TEXT

Format:

počítač and online zdroj

Description:

Wnt1 inducible protein-1 signaling pathway (WISP-1) is a relatively new adipokine involved in many cellular processes, including epithelial mucosa healing. The aim of the study was to compare circulating levels of WISP-1 and other selected adipokines [adiponectin, resistin and retinol-binding protein 4 (RBP-4)] in children with inflammatory bowel disease (IBD) with healthy controls and to investigate possible differences between Crohn's disease patients. (CD) or ulcerative colitis (UC). The study was performed as a case-control study. In addition to adipokines, anthropometric, lipid parameters, markers of inflammation or disease activity were evaluated in all participants. Compared to healthy controls (n=20), significantly lower levels of adiponectin and higher levels of resistin and WISP-1 were found in patients with IBD (n=58). Elevation of WISP-1 was detected only in the CD group (n=31). There were no differences in RBP-4 levels between the groups. Adiponectin, WISP-1 and RBP-4 were independently associated with body mass index only, resistin levels were associated with C-reactive protein levels and leukocyte counts. Adverse adipokines production reflects presence of dysfunctional fat tissue in IBD patients. Higher levels of WISP-1 in CD compared to patients with UC may indicate a specific role for mesenteric adipose tissue in WISP-1 production.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Coverage:

275-284

Source:

Physiological research | 2022 Volume:71 | Number:2

Harvested from:

CDK

Metadata only:

false