Influence of gender on ischemia-reperfusion injury in lungs in an animal model

Title:

Influence of gender on ischemia-reperfusion injury in lungs in an animal model

Creator:

Mrazkova, H., Lischke, R., and Herget, J.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:199ed739-ce06-410f-bbbe-6e3382ecca22
uuid:199ed739-ce06-410f-bbbe-6e3382ecca22

Subject:

Lung transplantation/ex vivo, Reperfusion injury/prevention and control, gender difference, and Animal model

Type:

article, model:article, and TEXT

Description:

As with other organ transplants even lung transplantation raises the question of the possibility of the influence of gender on ischemia -reperfusion injury. This is a current topic especially for increasingly utilized method of lung transplantation from non-heart-beating donors, where reperfusion preceded by a period of warm and cold ischemia with subsequent treatment options for lung graft reperfusion. For measurements we used our laboratory previously created and validated animal model for ex vivo lung transplantation. As with other organ systems of our monitoring resulted protective effect of female sex on ischemia reperfusion lung injury. In two of the three parameters that were monitored, we found a significant difference. In females, higher oxygen transfer ability after reperfusion was manifested as well as lower perfusion pressure (vascular compliance). Conversely, weight gain (the development of pulmonary edema) in males was not significant difference from the females. These conclusions could cause further studies leading to influence the selection of appropriate donor grafts.

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2016 Volume:65 | Number:6

Harvested from:

CDK

Metadata only:

false