Motor and behavioral changes in mice with cisplatin-induced acute renal failure

Title:

Motor and behavioral changes in mice with cisplatin-induced acute renal failure

Creator:

Ali, B. H., Ramkumar, A., Madanagopal, T. T., Waly, M. I., Tageldin, M., Al-Abri, S., Fahim, M., Yasin, J., and Nemmar, A.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:1b38c067-a9f3-4454-927c-1091a946675b
uuid:1b38c067-a9f3-4454-927c-1091a946675b

Subject:

Fyziologie člověka a srovnávací fyziologie, cisplatina, akutní selhání ledvin, myši, cisplatin, acute renal failure, mice, behavior, motor activity, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

We have previously shown that chronic renal failure in rats induces changes in motor activity and behavior. Similar work on the possible effects of acute renal failure (ARF) induced by cisplatin (CP) is lacking. This is the subject matter of the current work. CP was injected intraperitoneally (i.p.) at a single dose of 20 mg/kg to induce a state of ARF, and three days later, its effects on motor activity, thermal and chemical noci ceptive tests, neuromuscular coordination, pentobarbitone-sleeping time, exploration activity and tw o depression models were investigated. The platinum concentration in the kidneys and brains of mice was also measured. The occurrence of CP-induced ARF was ascertained by standard physiological, biochemical and histo-pathological methods. CP induced all the classical biochemical, physiological and histopathological signs of ARF. The average renal platinum concen tration of CP-treated mice was 5.16 ppm, but there was no measurable concentration of platinum in the whole brains. CP treatment significantly decreased motor and exploration activities, and increased immobility time in depression models, suggesting a possible depression-like state. There was also a significant decrease in neuromuscular coordination in CP-treated mice. CP, given at a nephrotoxic dose, induced several adverse motor and behavioral alterations in mice. Further behavioral tests and molecular and biochemical investigations in the brains of mice with CP-induced ARF are warranted., B. H. Ali ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2014 Volume:63 | Number:1

Harvested from:

CDK

Metadata only:

false