Effects of alprazolam on a model of human absences - rhythmic metrazol activity in rats

Title:

Effects of alprazolam on a model of human absences - rhythmic metrazol activity in rats

Creator:

Kubová, H. and Mareš, P.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:1de593e1-edd8-400b-92d2-4093b37da807
uuid:1de593e1-edd8-400b-92d2-4093b37da807

Subject:

epileptic seizures, EEG, pentylenetetrazol, alprazolam, and rat

Type:

article, model:article, and TEXT

Description:

Two doses of alprazolam (0.1 and 0.5 mg.kg“1) were tested against a model of human absences - rhythmic EEG activity elicited by low doses of pentylenetetrazol (35 mg.kg-1) - in 10 unrestrained rats with implanted cortical electrodes. Alprazolam delayed the onset of epileptic EEG activity, decreased the number of rhythmic episodes and shortened the total duration of rhythmic activity in a dose-dependent manner. The average duration of episodes of rhythmic activity remained unchanged; other benzodiazepines studied previously were able to influence this measure.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 1993 Volume:42 | Number:5

Harvested from:

CDK

Metadata only:

false