Antioxidant status and lipid peroxidation in diabetic rats under hyperbaric oxygen exposure

Title:

Antioxidant status and lipid peroxidation in diabetic rats under hyperbaric oxygen exposure

Creator:

Matsunami, T., Sato, Y., Sato, T., and Yukawa, M.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:1e882eaf-5e0c-4ec4-8835-82f439ee6b87
uuid:1e882eaf-5e0c-4ec4-8835-82f439ee6b87

Subject:

Fyziologie člověka a srovnávací fyziologie, oxidační stres, oxidative stress, hyperbaric oxygen, diabetic rats, lipid peroxidation, antioxidant enzyme, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

Hyperglycemia is known to cause oxidative stress that leads mainly to enhanced production of mitochondrial reactive oxygen species (ROS). It has been demonstrated that hyperbaric oxygen (HBO) treatment also increases the formation of ROS. There are, however, no comprehensive evaluations of such oxidative effects in diabetes which requires HBO treatment. The purpose of this study is to investigate the influence of a clinically-recommended HBO treatment on glucose homeostasis and oxidative stress in rats with streptozotocin (STZ)-induced diabetes. Under the clinically-used HBO exposure protocol, the levels of blood glucose, thiobarbituric acid reactive substances (TBARS) as a lipid peroxidation marker, and the activity of superoxide dismutase (SOD) as an antioxidant enzyme marker were investigated in the erythrocytes, liver, pancreas, skeletal muscle, and brain of rats with STZ-induced diabetes. The levels of blood glucose and TBARS increased significantly (p<0.05), and the activity of SOD decreased significantly (p<0.05) in the erythrocytes and all organs of rats with diabetes subjected to HBO exposure. These results suggested that HBO exposure might boost glucose autoxidation and increase ROS production in STZ-induced diabetes as side-effects of administering HBO treatment for the first time., T. Matsunami ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2010 Volume:59 | Number:1

Harvested from:

CDK

Metadata only:

false