Endocrine risk factors for COVID-19 in context of aging

Title:

Endocrine risk factors for COVID-19 in context of aging

Creator:

Máčová, Ludmila, Bičíková, Marie, and Hampl, Richard

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:1eab79a4-b60a-4b05-a4f5-22337b0a72f6
uuid:1eab79a4-b60a-4b05-a4f5-22337b0a72f6
doi:10.33549/physiolres.934723

Subject:

COVID-19, aging, endocrinopathy, immunity, and vitamin D

Type:

model:article and TEXT

Format:

počítač and online zdroj

Description:

Aged people are the most susceptible group to COVID-19 infection. Immunosenescence characterized by impairment of immune function with inflamm-aging contributes to pathophysiological alterations, among which endocrine and metabolic diseases are not exception. Diabetes, obesity along with impairment of disorders of thyroid functions are the most frequent ones, the common feature of which is failure of immune system including autoimmune processes. In the minireview we discussed how COVID-19 and aging impact innate and adaptive immunity, diabetes and selected neuroendocrine processes. Mentioned is also beneficial effect of vitamin D for attenuation of these diseases and related epigenetic issues. Particular attention is devoted to the role of ACE2 protein in the light of its intimate link with renin-angiotensin regulating system.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Coverage:

S153-S159

Source:

Physiological research | 2021 Volume:70 | Number:Supplement 2

Harvested from:

CDK

Metadata only:

false