Effects of L-arginine on prevention and treatment of lithium-pilocarpine-induced status epilepticus

Title:

Effects of L-arginine on prevention and treatment of lithium-pilocarpine-induced status epilepticus

Creator:

Noyan, B. and Güleç, G.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:20bf5076-24da-48a8-b7b6-ad25788c45cf
uuid:20bf5076-24da-48a8-b7b6-ad25788c45cf
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, oxid dusný, nitrous oxide, L-arginine, status epilepticus, rat, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

The effects of various doses of L-arginine, a nitric oxide substrate, on lithium-pilocarpine-induced seizures were studied in rats. Rats were implanted with chronic, stainless steel screw electrodes epidurally for electrocortical recordings. A control group received 3 mEq/kg LiCl (i.p.) and 24 h later 45 mg/kg pilocarpine HCl (i.p.). Two different experimental procedures were followed: (1) L-arginine was applied in doses of 100 mg/kg, 300 mg/kg or 500 mg/kg (i.p.), 30 min before pilocarpine injection; (2) 300 mg/kg, 500 mg/kg or 1000 mg/kg (i.p.) L-arginine was injected either 5 min or 30 min after the onset of status epilepticus (SE). L-arginine (300 mg/kg) injected 30 min before pilocarpine significantly reduced the percentage of SE, but did not change the latency to SE or 24-hour survival. These parameters were not significantly affected by the 100 mg/kg or 500 mg/kg dose of L-arginine. On the other hand, no dose of L-arginine that was applied after SE had begun, had any significant influence on the seizures. We concluded that L-arginine may prevent seizure activity in some but not all doses, and does not have any effect on the ongoing seizure activity., B. Noyan, G. Güleç., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2000 Volume:49 | Number:3

Harvested from:

CDK

Metadata only:

false