The effect of rosiglitazone on the expression of thrombogenic markers on leukocytes in type 2 diabetes mellitus

Title:

The effect of rosiglitazone on the expression of thrombogenic markers on leukocytes in type 2 diabetes mellitus

Creator:

Helena Svobodová, Tomáš Štulc, Zdislava Kasalová, Radka Doležalová, Iuri Marinov, Pavel Čapek, and Česka, R.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:20f1ce6a-1bb6-4c4e-8ac4-da1b75250bc6
uuid:20f1ce6a-1bb6-4c4e-8ac4-da1b75250bc6

Subject:

fyziologie, diabetes mellitus, marker, physiology, rosiglitazone, and thrombogenic markers

Type:

article, články, model:article, and TEXT

Description:

Diabetes mellitus is associated with a number of prothrombotic abnormalities, and correction of these abnormalities might translate into the reduction of cardiovascular risk. Glitazones improve endothelial function and reduce inflammation, but much less is known about their effect on thrombogenic factors. We have therefore studied the effect of rosiglitazone on leukocyte and soluble thrombogenic markers in patients with type 2 diabetes mellitus. Thirty-three subjects with type 2 diabetes and 32 normal controls were included; patients were examined at baseline and after 5 months of rosiglitazone treatment (4 mg/day). We measured leukocyte-platelet aggregates and leukocyte expression of either P-selectin glycoprotein ligand 1 (PSGL-1) or receptor for urokinase-type plasminogen activator (uPAR) using flow cytometry, as well as several circulating soluble thrombogenic markers by ELISA method. Leukocyte expression of uPAR and PSGL-1 was significantly higher in patients than in controls. Leukocyte-platelet aggregates and leukocyte expression of uPAR and PSGL-1 significantly decreased after rosiglitazone. There was also significant decrease in CRP and fibrinogen levels, but there was no effect of diabetes and/or rosiglitazone on other circulating molecules. In conclusions, we observed a substantial improvement in the expression of thrombogenic markers on leukocytes after rosiglitazone treatment, suggesting the novel antithrombotic effects of rosiglitazone., H. Svobodová ... [et al.]., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2009 Volume:58 | Number:5

Harvested from:

CDK

Metadata only:

false