Lisinopril indifferently improves heart rate variability during day and night periods in spontaneously hypertensive rats

Title:

Lisinopril indifferently improves heart rate variability during day and night periods in spontaneously hypertensive rats

Creator:

Albarwani, S., Al-Siyabi, S., and Tanira, M. O.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:21f828da-faa8-44bf-8355-8007102e931d
uuid:21f828da-faa8-44bf-8355-8007102e931d

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, heart rate variability, hypertension, circadian rhythm, lisinopril, ACE-inhibitor, telemetry, SHR, 14, and 612

Type:

article, články, model:article, and TEXT

Description:

The aim of this work was to investigate the effect of 10 weeks of lisinopril treatment to spontaneously hypertensive rats (SHRs) on day/night variations of blood pressure, heart rate and autonomic cardio-regulation parameters. Male SHR with surgically implanted radio-telemetry implant that provided direct measurements of arterial pressure and electrocardiogram wave were used. Animals were allocated to two groups (n=5 each). The first group was treated with lisinopril (20 mg/kg by gavage) daily for 10 weeks (treated group); whereas the second was gavaged daily with tap water (untreated group). Arterial blood pressure, ECG and other telemetry parameters were recorded at the start and at the end of 10-week treatment. Collected data were analyzed using specialized software and were statistically tested. In addition to the expected lowering of blood pressure, spectral analysis of R-R intervals revealed that lisinopril treatment for 10 weeks significantly caused 2-3 fold increase in heart rate variability (HRV) during both active and inactive periods. However, R-R interval durations demonstrated variable distribution patterns during those periods. The cause of observed distribution pattern of R-R intervals during active and inactive periods may be of significance to better understand HRV changes and warrants further investigations., S. Albarwani, S. Al-Siyabi, M. O. Tanira., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2013 Volume:62 | Number:3

Harvested from:

CDK

Metadata only:

false