Peripheral arterial stiffness in primary aldosteronism

Title:

Peripheral arterial stiffness in primary aldosteronism

Creator:

Jan Rosa, Z. Šomlóová, Ondřej Petrák, Branislav Štrauch, Indra, T., Šenitko, M., Tomáš Zelinka, Robert Holaj, and Jiří Widimský

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:22f2ff0c-e09c-4be8-9b49-5a3e43a040ff
uuid:22f2ff0c-e09c-4be8-9b49-5a3e43a040ff

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, peripheral arterial stiffness, primary aldosteronism, peripheral pulse wave velocity, 14, and 612

Type:

article, články, model:article, and TEXT

Description:

Aldosterone overproduction increases arterial wall stiffness by accumulation of different types of collagen fibres and growth factors. Our previous studies showed that central (aortic) arterial stiffness is increased in primary aldosteronism (PA) independently of concomitant hypertension and that these changes might be reversible after successful adrenalectomy. There is limited data available on the potential impact of mineralocorticoid overproduction on the deterioration of peripheral arterial stiffness. The current study was thus aimed at investigating the effect of aldosterone overproduction on peripheral arterial stiffness assessed by peripheral (femoralankle) pulse wave velocity (PWV) in PA patients compared with essential hypertension (EH) patients. Forty-nine patients with confirmed PA and 49 patients with EH were matched for age, blood pressure, body mass index, lipid profile, and fasting glucose. PWV was obtained using the Sphygmocor applanation tonometer. Both peripheral and central PWV were significantly higher in PA patients compared to EH patients, while clinical blood pressures were similar. Plasma aldosterone level was the main predictor of peripheral PWV in PA. Our data indicate aldosterone overproduction in PA does not preferentially affect central arterial system. Fibroproliferative effect of higher aldosterone levels lead to alteration of central-elastic as well as peripheral-muscular arteries with subsequent increase in its stiffness., J. Rosa ... [et al.]., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2012 Volume:61 | Number:5

Harvested from:

CDK

Metadata only:

false