Myocardial m6A regulators in postnatal development: effect of sex

Title:

Myocardial m6A regulators in postnatal development: effect of sex

Creator:

Semenovykh, Dmytro, Benak, Daniel, Holzerova, Kristyna, Cerna, Barbora, Telensky, Petr, Vavrikova, Tereza, Kolar, Frantisek, Neckar, Jan, and Hlavackova, Marketa

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:2444f6fb-459e-45bf-a874-692384f1b49b
uuid:2444f6fb-459e-45bf-a874-692384f1b49b
doi:10.33549/physiolres.934970

Subject:

epitranscriptomics, N6 -methyladenosine, postnatal development, and heart

Type:

model:article and TEXT

Format:

počítač and online zdroj

Description:

N6 -methyladenosine (m6 A) is an abundant mRNA modification affecting mRNA stability and protein expression. It is a highly dynamic process, and its outcomes during postnatal heart development are poorly understood. Here we studied m6 A machinery in the left ventricular myocardium of Fisher344 male and female rats (postnatal days one to ninety; P1-P90) using Western Blot. A downward pattern of target protein levels (demethylases FTO and ALKBH5, methyltransferase METTL3, reader YTHDF2) was revealed in male and female rats during postnatal development. On P1, the FTO protein level was significantly higher in males compared to females.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Coverage:

877-882

Source:

Physiological research | 2022 Volume:71 | Number:6

Harvested from:

CDK

Metadata only:

false