Brown fat activity determined by infrared thermography and thermogenesis measurement using whole body calorimetry (BRIGHT Study)

Title:

Brown fat activity determined by infrared thermography and thermogenesis measurement using whole body calorimetry (BRIGHT Study)

Creator:

Tay, Shi Huan, Goh, Hui Jen, Govindharajulu, Priya, Cheng, Jierong, Camps, Stefan Gerardus Joseph Anna, Haldar, Sumanto, Velan, Sambasivam Sendhil, Sun, Lei, Li, Yiqun, Henry, Christiani Jeyakumar, and Leow, Melvin Khee-Shing

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:24801818-e76c-4f36-9029-a2048765b92a
uuid:24801818-e76c-4f36-9029-a2048765b92a
doi:10.33549/physiolres.934190

Subject:

brown adipose tissue, infrared thermography, calorimetry, thermogenesis, and automation

Type:

model:article and TEXT

Format:

počítač and online zdroj

Description:

To assess BAT activity in humans at a population level, infrared thermography (IRT) represents a safe, readily repeatable and affordable alternative to 18F-FDG-PET. Building upon a previously proposed method by our laboratory, we further refined the image computational algorithm to quantify BAT activation in the cervical-supraclavicular (C-SCV) region of healthy young men under thermo-neutral and cold exposure conditions. Additionally, we validated the whole-body calorimeter (WBC) in reliably measuring cold-induced thermogenesis. The temperature gradient between C-SCV-deltoid regions, and the corresponding difference in heat power output, increased upon cold air exposure relative to thermo-neutral conditions (by 74.88 %, p<0.0001; and by 71.34 %, p<0.0001 respectively). Resting and cumulative energy expenditure (EE) rose significantly (by 13.14 % and 9.12 % respectively, p=0.0001) while positive correlations between IRT measures and EE were found with cold air exposure (percentage change in heat power gradient between ROI and deltoid, cold air: r2 =0.29, p=0.026, Pearson's correlation). IRT and WBC can be used to study BAT activation. The refined algorithm allows for more automation and objectivity in IRT data analysis, especially under cold air exposures.

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Coverage:

85-97

Source:

Physiological research | 2020 Volume:69 | Number:1

Harvested from:

CDK

Metadata only:

false