Neurogenic pulmonary edema induced by spinal cord injury in spontaneously hypertensive and dahl salt hypertensive rats

Title:

Neurogenic pulmonary edema induced by spinal cord injury in spontaneously hypertensive and dahl salt hypertensive rats

Creator:

Šedý, J., Jaroslav Kuneš, and Jiří Zicha

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:24cb926a-3553-47c7-9258-e0221cd1655d
uuid:24cb926a-3553-47c7-9258-e0221cd1655d

Subject:

Fyziologie člověka a srovnávací fyziologie, hypertenze, hypertension, rat, neurogenic pulmonary edema, SHR, dahl rats, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

Neurogenic pulmonary edema (NPE), which is induced by acute spinal cord compression (SCC) unde r the mild (1.5 %) isoflurane anesthesia, is highly dependent on baroreflex-mediated bradycardia because a deeper (3 %) isoflurane anesthesia or atropine pretreatment comple tely abolished bradycardia occurrence and NPE development in rats subjected to SCC. The aim of the present study was to evaluate whether hypertension- associated impairment of baroreflex sensitivity might exert some protection against NPE developmen t in hypertensive animals. We therefore studied SCC-induced NPE development in two forms of experimental hypertension - spontaneously hypertensive rats (SHR) and salt hypertensive Dahl rats, which were reported to have reduced baroreflex sensitivity. SCC elicited NPE in both hypertensive models irrespective of their baroreflex sensitivity. It is evident that a moderate impairment of baroreflex sensitivity, which was demonstrated in salt hypertensive Dahl rats, does not exert sufficient protective effects against NPE development., J. Šedý, J. Kuneš, J. Zicha., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2011 Volume:60 | Number:6

Harvested from:

CDK

Metadata only:

false