Biological effects of two successive shock waves focused on liver tissues and melanoma cells

Title:

Biological effects of two successive shock waves focused on liver tissues and melanoma cells

Creator:

Jiří Beneš, Pavel Šunka, Jarmila Králová, Kašpar, J., and Pavla Poučková

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:24fadb56-6a91-4bc1-a02d-e7431ff1c2d7
uuid:24fadb56-6a91-4bc1-a02d-e7431ff1c2d7
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, rázové vlny, fyziologie, shock waves, physiology, focused shock waves, double shocks, cavitation collapse, secondary shocks, liver injury, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

A new generator of two successive shock waves focused to a common focal point has been developed. Cylindrical pressure waves created by multichannel electrical discharges on two cylindrical composite anodes are focused by a metallic parabolic reflector - cathode, and near the focus they are transformed to strong shock waves. Schlieren photos of the focal region have demonstrated that mutual interaction of the two waves results in generation of a large number of secondary short-wavelength shocks. Interaction of the focused shockwaves with liver tissues and cancer cell suspensions was investigated. Localized injury of rabbit liver induced by the shock waves was demonstrated by magnetic resonance imaging. Histological analysis of liver samples taken from the injured region revealed that the transition between the injured and the healthy tissues is sharp. Suspension of melanoma B16 cells was exposed and the number of the surviving cells rapidly decreased with increasing number of shocks and only 8 % of cells survived 350 shocks. Photographs of cells demonstrate that even small number of shocks results in perforation of cell membranes., J. Beneš, P. Šunka, J. Králová, J. Kašpar, P. Poučková., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2007 Volume:56 | Number:Suppl 1

Harvested from:

CDK

Metadata only:

false