Effects of voluntary running exercise on skeletal muscle properties in nonobese rats with type 2 diabetes

Title:

Effects of voluntary running exercise on skeletal muscle properties in nonobese rats with type 2 diabetes

Creator:

Nakamoto, Isuzu and Ishihara, Akihiko

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:253b9e6d-3c9f-4a73-8d33-96fa4d59d3bd
uuid:253b9e6d-3c9f-4a73-8d33-96fa4d59d3bd
doi:10.33549/physiolres.934178

Subject:

Goto-Kakizaki rat, oxidative capacity, Pgc-1α mRNA, skeletal muscle, type 2 diabetes, and voluntary running exercise

Type:

model:article and TEXT

Format:

počítač and online zdroj

Description:

The skeletal muscles of animals and humans with type 2 diabetes have decreased oxidative capacity. Aerobic exercise can improve muscle oxidative capacity, but no data are available on the amount of exercise required. We investigated the effects of voluntary running exercise and running distance on the skeletal muscle properties of nonobese rats with type 2 diabetes. Six-week-old male diabetic Goto-Kakizaki rats were divided into nonexercised (GK) and exercised (GK-Ex) groups. The rats in the GK-Ex group were permitted voluntary running exercise on wheels for 6 weeks. Age-matched male Wistar rats (WR) were used as nondiabetic controls. Fasting blood glucose and HbA1c levels were higher in the GK and GK-Ex groups than in the WR group and lower in the GK-Ex group than in the GK group. Succinate dehydrogenase (SDH) activity and peroxisome proliferator-activated receptor γ coactivator-1α (Pgc-1α) mRNA levels in the soleus and plantaris muscles were higher in the WR and GK-Ex groups than in the GK group. HbA1c and total cholesterol levels were negatively correlated with running distance and SDH activity and Pgc-1α mRNA levels in the soleus muscle were positively correlated with running distance. The onset and progression of diabetes in nonobese diabetic rats were effectively inhibited by running longer distances.

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Coverage:

73-84

Source:

Physiological research | 2020 Volume:69 | Number:1

Harvested from:

CDK

Metadata only:

false