Effect of steroid hormone deprivation on the expression of Ecto-ATPase in distinct brain regions of female rats

Title:

Effect of steroid hormone deprivation on the expression of Ecto-ATPase in distinct brain regions of female rats

Creator:

Nedeljkovic, N., Djordjevic, V., Horvat, A., Nikezic, G., and Kanazir, D. T.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:263d9aa3-adaf-4c2f-9d8a-74d258304964
uuid:263d9aa3-adaf-4c2f-9d8a-74d258304964
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, mozek, brain, Ecto-ATPase, ovariectomy, adrenalectomy, extracellular nucleotides, rat brain, 14, and 612

Type:

article, články, journal articles, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Abundant evidence indicates that ATP and adenosine act as neurotransmitters or co-transmitters, influencing nerve cell physiology in various ways. Therefore, regulation of ATP-metabolizing enzymes is essential for the normal development and function of neuronal tissue. In the present study we have examined the effect of gonadal (OVX) or adrenal (ADX) steroid hormone deprivation on the activity and expression of synaptic membrane ecto-ATPase in three extrahypothalamic brain areas of female rats, primarily not associated with reproductive function. It was shown that OVX significantly increased ecto-ATPase activity and the relative abundance of this enzyme in the hippocampal (Hip) and caudate nucleus (CN), but not in brain stem (BS) membrane preparations. ADX was followed by an upregulation of the enzyme activity and its relative abundance in all the brain areas investigated. The highest enzyme activity and the most profound effects of OVX and ADX were detected in the CN. The results obtained indicate that ADX and OVX upregulate the expression of ecto-ATPase, potentiating the production of adenosine in synaptic cleft thus modulating the activity of numerous neurotransmitter systems in distinct areas of the CNS., N. Nedeljkovic, V. Djordjevic, A. Horvat, G. Nikezic, D.T. Kanazir., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2000 Volume:49 | Number:4

Harvested from:

CDK

Metadata only:

false