Erythropoietin decreases cytotoxicity and nitric oxide formation induced by inflammatory stimuli in rat oligodendrocytes

Title:

Erythropoietin decreases cytotoxicity and nitric oxide formation induced by inflammatory stimuli in rat oligodendrocytes

Creator:

Genc, K., Genc, S., Baskin, H., and Semin, I.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:2708469e-dfb6-4a3b-a9bc-7477e0ce3d05
uuid:2708469e-dfb6-4a3b-a9bc-7477e0ce3d05

Subject:

Erythropoietin, Oligodendrocyte, Cytotoxicity, Lipopolysaccharadie, Interferon-gamma, and Nitric oxide

Type:

article, model:article, and TEXT

Description:

In the present study, we investigated whether erythropoietin (Epo) has a protective effect against cytotoxicity induced by interferon-gamma (IFN- γ) and lipopolysaccharide (LPS) in primary rat oligodendrocyte cultures. The possible modulatory effect of erythropoietin on inducible nitric oxide synthase (iNOS) mRNA expression and nitrite production were also analyzed. Erythropoietin exerted a significant protective effect against IFN-γ and LPS-induced oligodendrocyte injury as determined by lactate dehydrogenase assay. Treatment with erythropoietin inhibited the expression of iNOS mRNA and nitrite production resulting from proinflammatory stimulation by IFN-γ and LPS. These results suggest that erythropoietin has protective effects against inflammatory oligodendrocyte injury in vitro and may play a protective role in neurological disorders characterized by oligodendrocyte death, such as multiple sclerosis.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2006 Volume:55 | Number:1

Harvested from:

CDK

Metadata only:

false