Long release latencies are increased by acetylcholine at frog endplate

Title:

Long release latencies are increased by acetylcholine at frog endplate

Creator:

Samigullin, D., Bukharaeva, E. A., Nikolsky, E., Svatopluk Adámek, and Vyskočil, F.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:2867d25f-2bcc-4959-bba4-2aab74c6d941
uuid:2867d25f-2bcc-4959-bba4-2aab74c6d941
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, acetylcholin, acetylcholine, quantal release, synaptic latency, model endplate current, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Uni-quantal endplate currents (EPCs) were recorded extracellularly at the frog neuromuscular synapse and their latency dispersions expressed as P90 were estimated in the presence of acetylcholine. Stimulation-evoked EPCs with long release latencies increased in number when acetylcholine was applied. P90, which is designated as the interval between the minimal synaptic delay and the time at which 90 % of all measured uni-quantal EPCs had occurred, was significantly and reversibly increased by 66% from 0.51 ms to 0.85 ms in the presence of 5x10-4 M acetylcholine. This indicates that the evoked release pattern is less synchronous and the increased asynchrony leads to a substantial drop (by 28%) in the amplitude of reconstructed multi-quantal currents., D. Samigullin, E. A. Bukharaeva, E. Nikolsky, S. Adámek, F. Vyskočil., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2003 Volume:52 | Number:4

Harvested from:

CDK

Metadata only:

false