Understanding the mechanism of LCAT reaction may help to explain the high predictive value of LDL/HDL cholesterol ratio

Title:

Understanding the mechanism of LCAT reaction may help to explain the high predictive value of LDL/HDL cholesterol ratio

Creator:

Dobiášová, M. and Frohlich, J.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:29306406-b631-473e-b634-9508a292f432
uuid:29306406-b631-473e-b634-9508a292f432

Subject:

reverse cholesterol transport, LCAT, atherosclerosis, LDL/HDL cholesterol ratio, and FERhdl

Type:

article, model:article, and TEXT

Description:

Traditionally, lecithinxholesterol acyltransferase (LCAT) role in the reverse cholesterol transport (RCT) has been considered "antiatherogenic" as the cholesterol esterification is the prerequisite for the formation of mature high density lipoprotein (HDL) particles and may create a gradient necessary for the flow of unesterified cholesterol (UC) from tissues to plasma. However, newer data suggest that a higher esterification rate is not necessarily protective. Here we review the available data on the role of LCAT in RCT and propose that the LCAT-mediated esterification of plasma cholesterol promotes RCT only in the presence of sufficient concentrations of HDL2 while this reaction may be atherogenic in the presence of high concentration of plasma low density lipoprotein (LDL) cholesteroL Thus, the "protective" or potentially "atherogenic" role of LCAT depends on the quality of HDL and concentration of LDL. This hypothesis is consistent with the known high predictive value of LDL/HDL cholesterol ratio.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 1998 Volume:47 | Number:6

Harvested from:

CDK

Metadata only:

false