Effects of atorvastatin and insulin in vascular dysfunction associated with type 2 diabetes

Title:

Effects of atorvastatin and insulin in vascular dysfunction associated with type 2 diabetes

Creator:

Sena, C. M., Matafome, P., Louro, T., Nunes, E., and Seiça, R. M.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:2c29350f-155c-4e11-bea6-8e9c61c3c707
uuid:2c29350f-155c-4e11-bea6-8e9c61c3c707

Subject:

Fyziologie člověka a srovnávací fyziologie, endoteliální dysfunkce, inzulin, endothelial dysfunction, insulin, type 2 diabetes, atorvastatin, Goto-Kakizaki rats, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

Atorvastatin and insulin have distinct mechanisms of action to improve endothelial function. Therefore, we hypothesized that atorvastatin and insulin therapies alone or in combination could have beneficial effects on en dothelium-dependent vascular reactivity, oxidative stress, inflammation and metabolic parameters in Goto-Kakizaki (GK) rats, a model of type 2 diabetes fed with atherogenic diet (GKAD). In parallel with the development of diabetes and lipid profile, the generation of oxidative stress was determined by measurement of lipid peroxides and oxidized proteins and the presence of inflammation was evaluated by assessing C-reactive protein (CRP). Additionally, endothe lial dependent and independent vascular sensitivity to acetylcholine and sodium nitroprusside were evaluated. GKAD showed increased carbonyl stress, inflammation, fasting glycemia, dyslipidemia and endothelial dysfunction when compared to control GK rats. Noteworthy, supplementation with insulin deteriorated endothelial dysfunction while atorvastatin induced an improvement. Atorvastatin and insulin therapies in combination improved metabolic parameters, CRP levels and insulin resistance indexes and ameliorated endothelial dysfunction in GKAD rats while they were unable to reduce urinary 8-isoprostranes and plasma carbonyl compounds. The therapeutic association of atorvastatin and insulin provided a better metabolic control with a reduction in endothelial dysfunction in GKAD rats by a mechanism that involves an improvement in systemic inflammation., C. M. Sena ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2014 Volume:63 | Number:2

Harvested from:

CDK

Metadata only:

false