Soluble leptin receptor levels in patients with chronic renal failure

Title:

Soluble leptin receptor levels in patients with chronic renal failure

Creator:

Jarmila Křížová, Sylvie Sulková, Vladimíra Bednářová, Jana Pařízková, Eva Kotrlíková, and Martin Haluzík

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:3013533d-4eb2-4444-92a3-9c1fa7913ef6
uuid:3013533d-4eb2-4444-92a3-9c1fa7913ef6
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, leptin, anorexie, anorexia, soluble leptin receptor, chronic renal failure, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Soluble leptin receptor (SLR) is the extracellular part of the leptin receptor. This protein is released into circulation and constitutes the main circulating leptin-binding protein. The aim of our study was to measure SLR concentrations in patients with chronic renal failure (CRF) and healthy subjects and to explore the relationship of SLR to other hormones and cytokines. The patients with CRF had significantly higher serum leptin, TNF-a and insulin levels than healthy subjects (25.1±23.5 vs. 9.4±7.6 ng.ml-1 (S.D.); 14.2±4.2 vs. 4.55±2.5 ng.ml-1; 39.8±36.1 vs. 20.3±11.1 mU.l-1). Serum soluble leptin receptor levels did not differ between these groups (19.1±11.3 vs. 19.6±6.1 U.ml-1). An inverse relationship between serum SLR and leptin levels was found in both groups. In patients with CRF the inverse relationship between SLR and insulin, body fat content and total protein levels were also found, while in healthy subjects only inverse relationship of SLR with insulin and albumin concentrations were detected. We conclude that soluble leptin receptor levels in patients with chronic renal failure do not differ from those of healthy subjects despite higher serum leptin levels in CRF patients. The physiological consequences of this finding require further investigation., J. Křížová, S. Sulková, V. Bednářová, E. Kotrlíková, M. Haluzík., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2003 Volume:52 | Number:3

Harvested from:

CDK

Metadata only:

false