Effects of Alprazolam and Fluoxetine on Morphine Sensitization in Mice

Title:

Effects of Alprazolam and Fluoxetine on Morphine Sensitization in Mice

Creator:

Martin Votava, Miloslav Kršiak, and Vladimír Moravec

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:306ba6c1-1a31-4473-80c6-e3e328a0eece
uuid:306ba6c1-1a31-4473-80c6-e3e328a0eece
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, Morphine, Alprazolam, Fluoxetine, Sensitization, Locomotion, 14, and 612

Type:

article, studie, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Benzodiazepines seem to be frequently abused in conjunction with opioids. Fluoxetine was reported to block morphine locomotor sensitization in rats. Sensitization has been implicated in some aspects of drug abuse. We have investigated the effect of alprazolam (0.25 mg/kg) and fluoxetine (5 mg/kg) on the development and expression of sensitization to the locomotor stimulant effect of morphine (10 mg/kg) in mice. Sensitization was produced by daily injections of morphine (10 mg/kg) for 10 days. There was a clear sensitization of locomotor activity produced by morphine in photocell activity cages but co-administration of alprazolam with morphine had no effect on the degree of sensitization. Alprazolam was also without effect on the expression of the sensitized response to morphine in mice sensitized with morphine alone. Fluoxetine partly reduced both the development and expression of morphine sensitization. In conclusion, the present experiments have not yielded evidence that alprazolam may influence the development or the expression of sensitization to morphine. However, they have corroborated and extended results indicating that fluoxetine can attenuate, to a certain level, the development and expression of morphine sensitization., M. Votava, M. Kršiak, V. Moravec., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2002 Volume:51 | Number:4

Harvested from:

CDK

Metadata only:

false