Short- versus long-term, gender and species differences in the intestinotrophic effects of long-acting glucagon-like peptide 2 analog

Title:

Short- versus long-term, gender and species differences in the intestinotrophic effects of long-acting glucagon-like peptide 2 analog

Creator:

Glerup, Peter, Sonne, Kim, Berner-Hansen, Mark, and Skarbaliene, Jolanta

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:316acafb-7f74-4549-9ca7-fe6e8a20cd9f
uuid:316acafb-7f74-4549-9ca7-fe6e8a20cd9f
doi:10.33549/physiolres.934839

Subject:

epithelia, glepaglutide, GLP-2 receptor, intestine, mucosa, receptor agonist, and short bowel syndrome

Type:

model:article and TEXT

Format:

počítač and online zdroj

Description:

Glucagon-like-peptide 2 (GLP-2) is an endogenous enteroendocrine physiological trophic peptide. Glepaglutide is a novel long-acting GLP-2 analog under development for the treatment of patients with Short Bowel Syndrome (SBS). The objective of this work was to compare the small intestinal trophic effects in both genders following short (1 week) versus long-term (26-39 weeks) GLP-2 treatment in Wistar rats and Beagle dogs. Following both short- and long-term treatment with glepaglutide, a significant dose-dependent intestinotrophic effect was seen in both genders and species. At all doses increased length and weight of the small intestine as well as macroscopic thickening and villous hypertrophy were noted in all segments of the small intestine, without any differences between genders. The findings were still present following a 6-week recovery period, indicating long-acting intestinotrophic effects of glepaglutide. These studies demonstrate that a long-acting GLP-2 analog (glepaglutide) has a fast onset and long duration of intestinotrophic action with similar profile in both genders and species (rat and dog).

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Coverage:

323-326

Source:

Physiological research | 2022 Volume:71 | Number:2

Harvested from:

CDK

Metadata only:

false