Nitric oxide synthase in pulmonary hypertension: lessons from knockout mice

Title:

Nitric oxide synthase in pulmonary hypertension: lessons from knockout mice

Creator:

Fagan, K. A., McMurtry, I., and Rodman, D. M.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:31baa4d6-7ebb-4fa4-97ed-6f2f07cd3867
uuid:31baa4d6-7ebb-4fa4-97ed-6f2f07cd3867
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, oxid dusnatý, plicní hypertenze, nitric oxide, pulmonary hypertension, knockout mice, pulmonary vasoreactivity, vascular remodeling, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Nitric oxide (NO) is implicated in a wide variety of biological roles. NO is generated from three nitric oxide synthase (NOS) isoforms: neuronal (nNOS), inducible (iNOS), and endothelial (eNOS) all of which are found in the lung. While there are no isoform-specific inhibitors of NOS, the recent development and characterization of mice deficient in each of the NOS isoforms has allowed for more comprehensive study of the importance of NO in the lung circulation. Studies in the mouse have identified the role of NO from eNOS in modulating pulmonary vascular tone and in attenuating the development of chronic hypoxic pulmonary hypertension., K. A. Fagan, I. McMurtry, D. M. Rodman., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2000 Volume:49 | Number:5

Harvested from:

CDK

Metadata only:

false