Gender Differences in Plasma Levels of Lipoprotein (a) in Patients with Angiographically Proven Coronary Artery Disease
- Title:
- Gender Differences in Plasma Levels of Lipoprotein (a) in Patients with Angiographically Proven Coronary Artery Disease
- Creator:
- Frohlich, J., Dobiášová, M., Adler, L., and Francis, M.
- Identifier:
- https://cdk.lib.cas.cz/client/handle/uuid:322af18a-c1c0-491c-a2a9-7ad8bfd130b1
uuid:322af18a-c1c0-491c-a2a9-7ad8bfd130b1 - Subject:
- Lipoúrotein(a), Gender, Coronary artery disease, Coronary angiography, and Immunoradiometric assay
- Type:
- article, model:article, and TEXT
- Description:
- The objective of the study was to assess the association between plasma levels of lipoprotein(a) [Lp(a)] and the presence of angiographically defined coronary artery disease (aCAD). Patients (346 men and 184 women) undergoing selective coronary angiography (SCA) were classified into groups with positive [aCAD(+)] and negative [aCAD(–)] findings and their age, body mass index (BMI), waist circumference, blood pressure, smoking, plasma total, LDL-, HDL-cholesterol (TC, LDL-C, HDL-C), triglycerides (TG), apolipoprotein B (apoB), Log(TG/HDL-C) and TC/HDL-C were determined. Concentration of plasma Lp(a) was estimated using the commercial solid phase two-side immunoradiometric assay of apolipoprotein apo(a). The plasma Lp(a) was significantly higher in both women and men with aCAD(+) compared to those with aCAD(–). While there was no significant difference in the Lp(a) level between men and women with aCAD(–) (median 138 vs. 145 units/l), the women with aCAD(+) had almost twice as high Lp(a) levels as men (median 442 vs. 274 units/l, p<0.001). Women with aCAD(+) had also significantly lower HDL cholesterol levels (1.09 vs. 1.20 mmol/l, p<0.05), higher triglycerides (1.82 vs. 1.46 mmol/l, p<0.05) and Log(TG/HDL-C) than women with aCAD(–). The differences in Lp(a) between positive and negative findings remained highly significant (p<0.001 in women, p<0.05 in men) after the adjustment for age, plasma HDL- and LDL-cholesterol and triglycerides in logistic regression analyses. In logistic regression model the Lp(a) and Log(TG/HDL-C) and smoking in women but smoking and age in men were the most powerful predictors of positive aCAD findings. Our findings suggest that Lp(a) is more strongly associated with aCAD+ in women than in men.
- Language:
- English
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public - Source:
- Physiological research | 2004 Volume:53 | Number:5
- Harvested from:
- CDK
- Metadata only:
- false
The item or associated files might be "in copyright"; review the provided rights metadata:
- http://creativecommons.org/licenses/by-nc-sa/4.0/
- policy:public