Genetic isolation of quantitative trait loci for blood pressure development and renal mass on chromosome 5 in the spontaneously hypertensive rat

Title:

Genetic isolation of quantitative trait loci for blood pressure development and renal mass on chromosome 5 in the spontaneously hypertensive rat

Creator:

Michal Pravenec, Vladimír Křen, Drahomíra Křenová, Václav Zídek, Miroslava Šimáková, Alena Musilová, Vorlíček, J., Lezin, E. St., and Kurzt, T. W.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:3267d7b2-0e8e-45be-95cf-b37e3c0e1f8c
uuid:3267d7b2-0e8e-45be-95cf-b37e3c0e1f8c
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, krevní tlak, blood pressure, SHR, congenic strain, chromosome 5, renal mass, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Total genome scans of genetically segregating populations derived from spontaneously hypertensive rats (SHR) and other rat models of essential hypertension suggested a presence of quantitative trait loci (QTL) regulating blood pressure on multiple chromosomes, including chromosome 5. The objective of the current study was to test directly a hypothesis that chromosome 5 of the SHR carries a blood pressure regulatory QTL. A new congenic strain was derived by replacing a segment of chromosome 5 in the SHR/Ola between the D5Wox20 and D5Rat63 markers with the corresponding chromosome segment from the normotensive Brown Norway (BN/Crl) rat. Arterial pressures were directly monitored in conscious, unrestrained rats by radiotelemetry. The transfer of a segment of chromosome 5 from the BN strain onto the SHR genetic background was associated with a significant decrease of systolic blood pressure, that was accompanied by amelioration of renal hypertrophy. The heart rates were not significantly different in the SHR compared to SHR chromosome 5 congenic strain. The findings of the current study demonstrate that gene(s) with major effects on blood pressure and renal mass exist in the differential segment of chromosome 5 trapped within the new SHR.BN congenic strain., M. Pravenec, V. Křen, D. Křenová, V. Zídek, M. Šimáková, A. Musilová, J. Vorlíček, E. St. Lezin, T. W. Kurtz., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2003 Volume:52 | Number:3

Harvested from:

CDK

Metadata only:

false