Study on effects of electrical stimulation on rabbit esophageal body motility in vivo

Title:

Study on effects of electrical stimulation on rabbit esophageal body motility in vivo

Creator:

Zhang, L, Wang, B, Jin, H, Zhao, W, and Zhao, C

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:32d2446a-235e-48e7-a31c-75434612eb99
uuid:32d2446a-235e-48e7-a31c-75434612eb99
issn:0862-8408

Subject:

fyziologie člověka, human physiology, Electrical stimulation, Esophagus motility, High-resolution manometry, 14, and 612

Type:

model:article and TEXT

Format:

print, bez média, and svazek

Description:

Electric stimulation (ES) could induce contraction of intestinal smooth muscle. The aim of this study was to analyze the effects of ES on esophageal motility and the underlying mechanism in vivo. Twenty-eight rabbits were equipped with a pair of subserosa electrodes (connected to an electrical stimulator) in the lower segment of the esophagus. The ES signal consisted of bipolar rectangular pulse trains, lasting for 3 s, with different amplitudes (1 mA, 3 mA, 5 mA and 10 mA), and frequencies (10 Hz, 20 Hz and 50 Hz). The amplitude of the contraction was recognized by high-resolution manometry. The effect of ES was tested under anesthesia and following administration of atropine, phentolamine or L-NAME. ES induced esophageal contraction at the stimulated site. A statistically significant increase in esophageal pressure was observed when the stimulation amplitude was above 3 mA. The increase in esophageal pressure was associated with the amplitude of stimulus as well as the frequency. During stimulation, atropine, phentolamine and L-NAME had no effect on the increase of esophageal pressure induced by ES. These findings implied that ES induced esophageal contraction were not mediated via the NANC, adrenergic or cholinergic pathway. The amplitude of esophageal contraction was current and frequency dependent., L. Zhang, W. Zhao, C. Zhao, H. Jin, B. Wang, B. Wang., and Seznam literatury

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2018 Volume:67 | Number:2

Harvested from:

CDK

Metadata only:

false