N-acetylcysteine advancement of surfactant therapy in experimental meconium aspiration syndrome: possible mechanisms

Title:

N-acetylcysteine advancement of surfactant therapy in experimental meconium aspiration syndrome: possible mechanisms

Creator:

Kopincová, J., Daniela Mokrá, Mikolka, P., Kolomazník, M., and Andrea Čalkovská

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:32f56a5e-4228-4000-9c41-329b5f57b3f5
uuid:32f56a5e-4228-4000-9c41-329b5f57b3f5
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, povrchově aktivní látky, surfactants, meconium aspiration, surfactant inactivation, N-acetylcysteine, oxidative damage, neutrophils, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Meconium aspiration syndrome (MAS) is meconium-induced respiratory failure of newborns associated with activation of inflammatory and oxidative pathways. For severe MAS, exogenous surfactant treatment is used which improves respiratory functions but does not treat the inflammation. Oxidative process can lead to later surfactant inactivation; hence, surfactant combination with antioxidative agent may enhance the therapeutic effect. Young New Zealand rabbits were instilled by meconium suspension and treated by surfactant alone, Nacetylcysteine (NAC) alone or by their combination and oxygenventilated for 5 h. Blood samples were taken before and 30 min after meconium application and 30 min, 1, 3 and 5 h after the treatment for evaluating of oxidative damage, total leukocyte count, leukocyte differential count and respiratory parameters. Leukocyte differential was assessed also in bronchoalveolar lavage fluid. NAC alone had only mild therapeutic effect on MAS. However, the combination of NAC and surfactant facilitated rapid onset of therapeutic effect in respiratory parameters (oxygenation index, PaO2/FiO2) compared to surfactant alone and was the only treatment which prevented neutrophil migration into the lungs, oxidative damage and lung edema. Moreover, NAC suppressed IL-8 and IL-β formation and thus seems to be favorable agent for improving surfactant therapy in MAS., J. Kopincová, D. Mokrá, P. Mikolka, M. Kolomazník, A. Čalkovská., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2014 Volume:63 | Number:Suppl 4

Harvested from:

CDK

Metadata only:

false