FLIM analysis of intracellular markers associated with the development of Parkinson's disease in cellular model

Title:

FLIM analysis of intracellular markers associated with the development of Parkinson's disease in cellular model

Creator:

Pokusa, M. and Kráľová Trančíková, A.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:33a3d6f4-97cf-478b-a6fd-61ecd771bae2
uuid:33a3d6f4-97cf-478b-a6fd-61ecd771bae2

Subject:

fluorescence lifetime imaging, FLIM, SH-SY5Y, cellular model, rotenone, and Parkinson's disease

Type:

model:article and TEXT

Format:

bez média and svazek

Description:

Parkinson's disease (PD) is currently the second most common neurodegenerative disorder in the world. Major features of cell pathology of the disease include the presence of cytoplasmic inclusions called Lewy bodies, which are composed of aggregated proteins. The presence of Lewy's body is associated with more advanced stages of the disease when considering irreversible changes. Precise identification of the disease stage at a cellular level presents the critical tool in developing early diagnostics and/or prevention of PD. The aim of our work is to introduce sensitive microscopic analysis in living cells, focused on initial intracellular changes and thus capable to detect earlier stages of the disease.

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2018 Volume:67 | Number:Suppl 4

Harvested from:

CDK

Metadata only:

false