The homogeneous effect of calcium ionophore A23187 on potassium loss in human foetal red cell populations

Title:

The homogeneous effect of calcium ionophore A23187 on potassium loss in human foetal red cell populations

Creator:

Serrani, R. E., Gioia, I. A., and Corchs, J. L.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:360c101f-3f16-4d12-ac31-39d05d27f80b
uuid:360c101f-3f16-4d12-ac31-39d05d27f80b

Subject:

foetal red cells, calcium Ionophore, and potassium loss

Type:

article, model:article, and TEXT

Description:

A "pulse like" increase of cytoplasmic calcium concentration, which is proportional to ionophore concentration, is induced in red cells by exposure to A23187- Different Ca2+ levels are attained depending on cellular calcium buffering power and/or primary active calcium transport activation. We examined the effect of A23187 concentration on potassium loss in neonatal (nRC) as well as in adult red cells (aRC). The increase in ionophore concentration produced an "all- or -none" recruitment in adult cells and a "gradual" one in neonatal red cells. The "gradual" response observed in nRC would suggest that the "all or none" character of the response is not present in red cells during the foetal stages of haematopoiesis.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 1995 Volume:44 | Number:5

Harvested from:

CDK

Metadata only:

false