Ibotenate lesion of the ventromedial hypothalamus lowers hyperthermic effects of prostaglandin E1

Title:

Ibotenate lesion of the ventromedial hypothalamus lowers hyperthermic effects of prostaglandin E1

Creator:

Monda, M., Sullo, A., Luca, V. de, and Viggiano, A.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:37293845-65cc-4776-9319-32e92b219de2
uuid:37293845-65cc-4776-9319-32e92b219de2
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, centrální nervový systém, hypertermie, central nervous system, hyperthermia, brown adipose tissue, pyrogen, rat, sympathetic activity, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

This experiment tested the effects of an intracerebroventricular injection of prostaglandin E1 on the sympathetic activation and the thermogenic changes in rats with ibotenate lesions of the ventromedial hypothalamus. Under pentobarbital anesthesia, twelve Sprague-Dawley male rats were lesioned bilaterally in the ventromedial hypothalamus with an injection of ibotenic acid (30 nmol into each side). Sham lesions were carried out in other twelve control rats. After 48 h, all animals were anesthetized with ethyl-urethane. The firing rate of the sympathetic nerves innervating the interscapular brown adipose tissue and the colonic and interscapular brown adipose tissue temperatures were monitored before and after an intracerebroventricular injection of prostaglandin E1 (500 ng) or saline. Prostaglandin E1 induced an increase in the firing rate of sympathetic nerves and the colonic and interscapular brown adipose tissue temperatures. These effects were reduced by the ventromedial hypothalamic lesion. Since ibotenic acid destroys cell bodies, the findings indicate that neurons of the ventromedial hypothalamus play a considerable role in the control of sympathetic activation and the thermogenic changes during prostaglandin E1 hyperthermia., M. Monda, A. Sullo, V. De Luca, A. Viggiano., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2001 Volume:50 | Number:3

Harvested from:

CDK

Metadata only:

false