New clearance evaluation method for hepatological diagnostics

Title:

New clearance evaluation method for hepatological diagnostics

Creator:

Josef A. Tichý, Miloslav Loučka, Trefný, Z. M., Markéta Hojerová, Jiří Svačinka, Müller, J., and Michaela Friedrichová

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:38416019-82b4-454b-aea1-280ed23103e0
uuid:38416019-82b4-454b-aea1-280ed23103e0

Subject:

Patologie. Klinická medicína, fyziologie, farmakokinetika, nelineární regresní modely, physiology, pharmacokinetics, nonlinear regression models, steatofibrosis hepatis (SFH), indocyanin green, two-compartment model, non-linear regression analysis, clearance value, T-index, 14, and 616

Type:

article, články, model:article, and TEXT

Format:

print

Description:

Pulse dye densitometry (PDD) enables the evaluation of hemodynamic state as well as liver function. A repeated examination, even after a short pause (or under stress condition), enables to follow safely the dynamics of liver pathology. From presented parameters we have evaluated as reliable the C5-clearance, an expression of equilibrium state in the two compartment liver system. Furthermore, T-index expresses ratio of C5 value to cardiac output, it is a sensitive indicator of the blood pole, i.e. sinusoidal uptake, which is in very good correlation with staging of hepatopathies. The isolated h constant in correlation to T-index is valuable For functional grading. The Japanese automatic analyzer of indocyanine green (ICG) dilution and elimination curves, after incorporation of a two compartment mathematical mode l, becomes more useful for complex hepatological diagnostics. Non-invasive PDD is becoming of uppermost importance to clinic al interest, yielding comparable results as other complicated and invasive examinations and may be, therefore, repeated in short time intervals for different indications with minimal stress of examined patient., J. A. Tichý ... [et al.]., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2009 Volume:58 | Number:2

Harvested from:

CDK

Metadata only:

false