Determination of homocysteine in cerebrospinal fluid as an indicator for surgery treatment in patients with hydrocephalus

Title:

Determination of homocysteine in cerebrospinal fluid as an indicator for surgery treatment in patients with hydrocephalus

Creator:

Sosvorová, L., Bešťák, J, Marie Bičíková, Milan Mohapl, Hill, M., Kubátová, J., and Richard Hampl

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:38e029af-6580-4e08-b9e9-9e88782b241a
uuid:38e029af-6580-4e08-b9e9-9e88782b241a
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, homocystein, mozkomíšní mok, hydrocefalus, homocysteine, cerebrospinal fluid, hydrocephalus, shunt, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Increased homocysteine levels in serum are typical features of neurodegenerative brain diseases including hydrocephalus. The most frequent therapeutic approach consists of the insertion of a shunt, connecting the brain ventricles to an alternative drainage site. To decide whether the patient should undergo this, the lumbar drainage test is usually carried out to distinguish patients who can benefit from the shunt insertion. In searching for other potential biochemical markers for shunt indication we determined homocysteine levels in CSF during the lumbar drainage test. Homocysteine in CSF was measured during the 5-day lumbar drainage test in 27 patients with normal-pressure hydrocephalus (NPH) and in 25 patients with excluded hydrocephalus. A novelized gas chromatography method with flame ionization detection (GC-FID) was developed and evaluated. During the first two days of lumbar drainage, the levels of CSF homocysteine in NPH patients were significantly higher compared to the controls, while on the fifth day, the homocysteine levels in patients with hydrocephalus reached the level of controls. Determination of CSF homocysteine in patients with confirmed or suspected hydrocephalus may serve as an independent marker for deciding on their further treatment strategy., L. Sosvorová, J. Bešťák, M. Bičíková, M. Mohapl, M. Hill, J. Kubárová, R. Hampl., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2014 Volume:63 | Number:4

Harvested from:

CDK

Metadata only:

false