DNA damage caused by ionizing radiation in embryonic diploid fibroblasts WI-38 induces both apoptosis and senescence

Title:

DNA damage caused by ionizing radiation in embryonic diploid fibroblasts WI-38 induces both apoptosis and senescence

Creator:

Jana Ćmielová, Havelek, R., Jiroutová, A., Renata Köhlerová, Martina Seifrtová, Muthná, D., Jiřina Vávrová, and Martina Řezáčová

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:3904d208-9226-4f91-ac15-cb6f1d803baa
uuid:3904d208-9226-4f91-ac15-cb6f1d803baa

Subject:

Fyziologie člověka a srovnávací fyziologie, ionizující záření, kmenové buňky, ionizing radiation, stem cells, DNA damage, senescence, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

Cellular response to ionizing radiation-induced damage depends on the cell type and the ability to repair DNA damage. Some types of cells undergo apoptosis, whereas others induce a permanent cell cycle arrest and do not proliferate. Our study demonstrates two types of response of embryonic diploid fibroblasts WI-38 to ionizing radiation. In the WI-38 cells p53 is activated, protein p21 increases, but the cells are arrested in G2 phase of cell cycle. Some of the cells die by apoptosis, but in remaining viable cells p16 increases, senescence associated DNA- damage foci occur, and senescence-associated beta-galactosidase activity increases, which indicate stress-induced premature senescence., J. Cmielová ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2011 Volume:60 | Number:4

Harvested from:

CDK

Metadata only:

false