Characteristic Enhancement of Blood Pressure V-Shaped Waves in Sinoaortic-Denervated Rats in a Conscious and Quiet State

Title:

Characteristic Enhancement of Blood Pressure V-Shaped Waves in Sinoaortic-Denervated Rats in a Conscious and Quiet State

Creator:

Chang, Huan, Gu, Hong-Xia, Gong, Min, Han, Ji-Ju, Wang, Yun, Xia, Zuo-Li, and Zhao, Xiao-Min

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:3964850a-3174-4277-91f2-d613d0d7bf02
uuid:3964850a-3174-4277-91f2-d613d0d7bf02

Subject:

Rat, Sinoaortic denervation, Nerve, Blood pressure, and Blood pressure variability

Type:

article, model:article, and TEXT

Description:

A hemodynamic feature of chronic sinoaortic -denervated (SAD) rats is the increase in blood pressure variability (BPV) without significant change s in the average level of blood pressure (BP). The current study was designed to investigate the changes in BP V- shaped waves (V waves) in SAD rats. Sprague -Dawley (SD) rats were divided into 2 groups: SAD rats and sham -operated rats (n=13 ). Hemodynamics measurements were obtained in conscious, freely moving rats, four weeks after sinoaortic denervation or sham operation. V wave indices were evaluated in rats in both conscious and quiet states. Additionally, n ormal and high BPV was simulate d by the production of V waves with different amplitudes. The results showed that the V wave amplitude was dramatically increased, with a significantly prolonged duration and reduced frequency in SAD rats . V wave BPV in SAD rats was significantly increased , though BP remained unchanged. The twenty -four hour BPV in all rats was positively correlated with amplitude, duration time and V wave BPV and negatively correlated with frequency. The systolic BP spectral powers in the low frequency range (0.38 -0.45 Hz) were significantly reduced in the V waves of SAD rats. Moreover, there was a remarkable increase in mean BPV and a normal mean BP after simulating high BPV in SAD rats . The se results suggest that enhancement of V waves might be a waveform character of BP in SAD rats in both the conscious and quiet states. These types of V waves appear to be related to a depression of sympathetic regulation of BP induced by sinoaortic denervation.

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2016 Volume:65 | Number:4

Harvested from:

CDK

Metadata only:

false