Cathelicidin LL-37 improves bone metabolic balance in rats with ovariectomy-induced osteoporosis via the Wnt/β-catenin pathway

Title:

Cathelicidin LL-37 improves bone metabolic balance in rats with ovariectomy-induced osteoporosis via the Wnt/β-catenin pathway

Creator:

Liang, Jianwei, Chen, Jianjun, Ye, Zhan, and Bao, Dandan

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:3969f4ad-dbd4-43a1-8a66-7ca26b9c83e5
uuid:3969f4ad-dbd4-43a1-8a66-7ca26b9c83e5
doi:10.33549/physiolres.934820

Subject:

LL-37, osteoporosis, bone metabolism, and Wnt/β-catenin pathway

Type:

model:article and TEXT

Format:

počítač and online zdroj

Description:

Osteoporosis is a bone disease characterized by low bone mineral density (BMD) and impaired bone microarchitecture due to the abnormal activity of osteoclasts. Cathelicidins are antimicrobial peptides present in the lysosomes of macrophages and polymorphonuclear leukocytes. LL-37, a cathelicidin, induces various biological effects, including modulation of the immune system, angiogenesis, wound healing, cancer growth, as well as inflammation, and bone loss. A previous study reported direct involvement of LL-37 suppressing osteoclastogenesis in humans. Here, we examined the role of LL-37 in the treatment of osteoporosis using an ovariectomy (OVX) rat model. Our results showed that LL-37 significantly reduced bone loss and pathological injury in OVX rats with osteoporosis. Furthermore, we found that LL-37 significantly increased the activity of the Wnt/β-catenin pathway in OVX rats with osteoporosis, including the increased expression of β-catenin, Osterix (Osx), and Runt-related transcription factor 2 (Runx2), whereas XAV-939, an inhibitor of the Wnt/β-catenin pathway, significantly blocked the effects of LL-37 on bone loss and abnormal bone metabolism. Altogether, our findings suggested that LL-37 exerted a protective role in regulating bone loss and abnormal bone metabolism in rats with osteoporosis by activating the Wnt/β-catenin pathway.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Coverage:

369-377

Source:

Physiological research | 2022 Volume:71 | Number:3

Harvested from:

CDK

Metadata only:

false