Aspalathin, a C-glucosyldihydrochalcone from rooibos improves the hypoglycemic potential of metformin in type 2 diabetic (db/db) mice

Title:

Aspalathin, a C-glucosyldihydrochalcone from rooibos improves the hypoglycemic potential of metformin in type 2 diabetic (db/db) mice

Creator:

Dludla, P. V, Gabuza, K. B, Muller, C. J. F, Joubert, E, Louw, J, and Johnson, R

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:3aba6960-07a0-455c-b66c-9dafd7ca36a9
uuid:3aba6960-07a0-455c-b66c-9dafd7ca36a9
issn:0862-8408

Subject:

diabetes mellitus, aspalathin, metformin, combination therapy, 14, and 612

Type:

model:article and TEXT

Format:

print, bez média, and svazek

Description:

Metformin is the first line therapy of type 2 diabetics, but continued reduction of their life expectancy warrants further investigation into alternative treatment strategies. This study reports on the combinational use of metformin with aspalathin, a C-glucosyl dihydrochalcone with known glucose lowering and antioxidant properties, as an effective hypoglycemic therapy in a type 2 diabetic (db/db) mouse model. When tested as a monotherapy, a low dose of aspalathin (13 mg/kg) showed no effect, while a high dose (130 mg/kg) has already displayed a better potential than metformin in protecting against diabetes associated symptoms in db/db mice. Thus, it remains of interest to determine whether this dihydrochalcone can improve the efficacy of metformin. The results showed that this combination therapy was more effective than the use of metformin as a monotherapy in ameliorating diabetes associated symptoms, including abnormal raised fasting plasma glucose levels, impaired glucose tolerance, as well as excessively increased body weights and fat content. The treated mice also had reduced food and water consumption when compared to untreated controls, with a pronounced effect evident in the last week of treatment. Therefore, this study supports further investigations into the ameliorative effect of combination therapy of metformin and aspalathin against diabetes associated symptoms., P. V. Dludla, K. B. Gabuza, C. J. F. Muller, E. Joubert, J. Louw, R. Johnson., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2018 Volume:67 | Number:5

Harvested from:

CDK

Metadata only:

false