Biomarkers of cardiometabolic risk in obese/overweight children: effect of lifestyle inetrvention

Title:

Biomarkers of cardiometabolic risk in obese/overweight children: effect of lifestyle inetrvention

Creator:

Michal Vrablík, Milada Dobiášová, Lukáš Zlatohlávek, Zuzana Urbanová, and Richard Češka

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:3e77317a-0f16-48bf-8a49-943957abce6d
uuid:3e77317a-0f16-48bf-8a49-943957abce6d
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, obézní děti, obezita, overweight children, obesity, AIP [Log(TG/HDL-C)], ApoB/apoAI ratio, HOMA-IR (insulin resistance), cardiometabolic risk markers, intensive lifestyle intervention, obese children, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Obesity is a strong cardiometabolic (CM) risk factor in children. We tested potential CM risk in obese/overweight children and the effect of an intensive lifestyle intervention using newer CM markers: atherogenic index of plasma AIP [Log(TG/HDL-C)], apoB/apoAI ratio and a marker of insulin resistance HOMA-IR. The participants (194 girls, 115 boys, average age 13) were enrolled in an intensive, one-month, inpatient weight reduction program. The program consisted of individualised dietary changes and the exercise program comprised aerobic and resistance training. Anthropometrical and biochemical parameters in plasma and CM risk biomarkers - (AIP, apoB/apoAI ratio and HOMA-IR) were examined before and after the intervention. AIP and HOMA-IR significantly correlated with BMI while apoB/apoAI ratio did not. Only AIP and HOMA-IR showed systematic increases according to the level of obesity by BMI quartiles. Lifestyle intervention significantly improved anthropometrical and biochemical values and the biomarkers too. The response of lipid parameters to the intervention was considerably higher in boys than in girls. The children were stratified into three risk categories according to AIP, where 13.8 % of boys and 5.3 % of girls fell into high risk category. The monitored biomarkers may complement each other in the prognosis of CM risk. AIP was strongly related to obesity and to lipid and glycid metabolism, while the relationship of the apoB/apoAI ratio to obesity and glycid metabolism was not significant. The obese children benefited from the intensive lifestyle intervention which improved the anthropometrical and biochemical parameters and CM risk biomarkers., M. Vrablík, M. Dobiášová, L. Zlatohlávek, Z. Urbanová, R. Češka., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2014 Volume:63 | Number:6

Harvested from:

CDK

Metadata only:

false