Role of hereditary factors in weight loss and its maintenance

Title:

Role of hereditary factors in weight loss and its maintenance

Creator:

Vojtěch Hainer, Hana Zamrazilová, Spálová, Jana, Irena Aldhoon Hainerová, Marie Kunešová, Bashar Aldhoon, and Běla Bendlová

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:42b4ce04-9fbc-443a-90d2-fa95d8016760
uuid:42b4ce04-9fbc-443a-90d2-fa95d8016760
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, endokrinologie, obezita, genetické aspekty, environmentální aspekty, redukce tělesné hmotnosti, endocrinology, obesity, genetic aspects, environmental aspects, weight loss, weight maintenance, obesity candidate genes, gene polymorphisms, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

The prevalence of obesity is increasing worldwide at an alarming rate in both developed and developing countries. Obesity is a chronic complex disease of multifactorial origin resulting from a long-term positive energy balance, in which both genetic and environmental factors are involved. Genetically prone individuals are the first to accumulate fat in the present obesogenic environment. Obesity increases the risks of type 2 diabetes, hypertension, cardiovascular disease, dyslipidemia, arthritis, and several cancers and reduces the average life expectancy. Implementation of effective strategies in prevention and management of obesity should be come an important target in health care systems. Weight changes throughout life depend on the interaction of behavioral, genetic and environmental factors. Weight loss in response to weight management shows a wide range of interindividual variation which is largely influenced by genetic determinants. The strong control of weight loss by genotype was confirmed by twin and family studies. Recently, special attention has been paid to nutritional, hormonal, psychobehavioral and genetic factors which can predict the response to weight reduction programme. In this article currently available data on the role of obesity candidate gene polymorphisms in weight loss and maintenance are reviewed. It is believed that an elucidation of the genetic component in the prognosis of weight management could assist in the development of more effective and individually tailored therapeutic strategies., V. Hainer, H. Zamrazilová, J. Spálová, I. Hainerová, M. Kunešová, B. Aldhoon, B. Bendlová., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2008 Volume:57 | Number:Suppl 1

Harvested from:

CDK

Metadata only:

false