Effect of stimulation of sublobule IX-b of the cerebellar vermis on cardiac function

Title:

Effect of stimulation of sublobule IX-b of the cerebellar vermis on cardiac function

Creator:

Rocha, Isabel, Gonçalves, V., Bettencourt, M. J., and Silva-Carvalho, L.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:4322079f-2098-43df-ab0a-401c326f1e46
uuid:4322079f-2098-43df-ab0a-401c326f1e46
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie, mozeček, nervový systém, physiology, cerebellum, nervous system, vermis, cardiac function, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Activation of sublobule IX-b of the cerebellar vermis evokes hypotension, bradycardia and decrease of the phrenic nerve activity in the anesthetized animal. Cardiac performance during the isovolumic phases of systole and relaxation can be evaluated by dP/dt max, Vpm, dP/dt/DP40 and τ, respectively. In the present study, we evaluated the changes on cardiac function evoked by the stimulation of sublobule IX-b. New Zealand white rabbits were anesthetized, paralyzed and artificially ventilated. A posterior craniotomy was made to reveal and stimulate the cerebellar uvula (4 s train; 50 Hz; 1 ms; 20 μA). The femoral artery and veins were cannulated and a Swan-Ganz catheter was advanced in the upper abdominal aorta to control afterload when inflating the balloon. The left ventricle was catheterized with a Millar catheter. Blood pressure, heart rate, left ventricular pressure were monitored. Results showed a significant decrease on sublobule IX-b stimulation of all the indices of systolic function and an increase of τ indicating a decrease in the speed of the relaxation. These data provide the first evidence of the influence of sublobule IX-b on cardiac function. They may contribute to the understanding of the origin the cardiovascular changes that were observed in two patients with vermian and paravermian hemorrhage., I. Rochas, V. Gonçalves, M. J. Bettencourt, L. Silva-Carvalho., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2008 Volume:57 | Number:5

Harvested from:

CDK

Metadata only:

false