Vitamin D supplementation changed relationships, not levels of metabolic-hormonal parameters in autoimmune thyroiditis

Title:

Vitamin D supplementation changed relationships, not levels of metabolic-hormonal parameters in autoimmune thyroiditis

Creator:

Karel Vondra, Radovan Bílek, Petr Matucha, Salátová, M., Vosátková, M., Luboslav Stárka, and Richard Hampl

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:44568e91-9a7b-49b5-8254-15fc8a24e070
uuid:44568e91-9a7b-49b5-8254-15fc8a24e070
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, vitamin D, vitamin D deficiency, autoimmune thyroiditis, supplementation of vitamin D, 14, and 612

Type:

article, články, journal articles, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

In women with chronic autoimmune thyroiditis and vitamin D deficiency we have found reference levels of relevant metabolichormonal parameters except for parathormone and total calcium. Three months supplementation with vitamin D (4300 IU/day, cholekalciferol) did not lead to significant changes of investigated hormonal parameters, while the levels of parathormone and calcium reached normal levels. However, a correlation analysis revealed marked changes in mutual relations. First, an inverse correlation of vitamin D with parathormone, insulin secretion (C peptide, insulin) and its efficiency (HOMA IR) disappeared. Relationships of vitamin D to hepatic insulin resistance (insulin/C peptide), to DHEA (both negative), and to DHEAS/DHEA ratio (positive) were newly found. Second, a positive correlation of CRP with insulin secretion remained, while its relation to insulin efficiency (HOMA IR, insulin/ C peptide) was newly observed. Analogical positive correlations appeared also among anti TPO and insulinemia, insulin/C peptide, HOMA IR, and anti Tg to C peptide. A relationship of the CRP with anti TPO became significant (+). Third, out of glucose metabolism parameters only insulin/C peptide and glycemia did not correlate with vitamin D during its deficiency, while after supplementation insulin/ C peptide alone correlated positively with both DHEAS and DHEA, and negatively with vitamin D., K. Vondra, R. Bílek, P. Matucha, M. Salátová, M. Vosátková, L. Stárka, R. Hampl., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2017 Volume:66 | Number:Suppl 3

Harvested from:

CDK

Metadata only:

false