Interaction between glycine and glutamate in the development of spontaneous motility in chick embryos

Title:

Interaction between glycine and glutamate in the development of spontaneous motility in chick embryos

Creator:

Sedláček, J.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:4477eda6-324d-4f80-b10f-57ad191e1d4d
uuid:4477eda6-324d-4f80-b10f-57ad191e1d4d

Subject:

chick embryo, spontaneous motility, glycine, glutamate, and NMDA receptor

Type:

article, model:article, and TEXT

Description:

In this study we investigated whether also glycine fullfils the function as co-activator in glutamatergic activation of NMDA receptors in the neuronal apparatus of spontaneous motility in chick embryos.The successive application of glycine (5 or 10 mg/kg egg weight (e.w.) and glutamate (15 mg/kg e.w.) in a 10 min interval significantly increased the activation of spontaneous motility of 17-day-old chick embryos in comparison with the effect of glutamate alone. This effect did not depend on the order of application of the drugs. In 13-day-old embryos, glycine was ineffective in both doses. It is concluded from these results that the modulatory effect of glycine is evidently a later developmental acquisition (after day 15 of incubation) in the embryogenesis of NMDA-ergic activation of spontaneous motility in chick embryos similarly as glycinergic inhibition.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 1994 Volume:43 | Number:6

Harvested from:

CDK

Metadata only:

false