Changes in neuronal activity of the inferior colliculus in rat after temporal inactivation of the auditory cortex

Title:

Changes in neuronal activity of the inferior colliculus in rat after temporal inactivation of the auditory cortex

Creator:

Jiří Popelář, Nwabueze-Ogbo, F. C., and Josef Syka

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:44e7c1d0-9488-4907-94d8-dfddb0ba83bd
uuid:44e7c1d0-9488-4907-94d8-dfddb0ba83bd
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, neurony, neurons, inferior colliculus, auditory cortex, functional ablation, descending pathway, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

The role of cortico-tectal pathways in auditory signal processing was studied in anesthetized rats by comparing the extracellular single unit activity in the inferior colliculus (IC) before and after functional ablation of the auditory cortex (AC) by tetrodotoxin (TTX). The responses of several IC neurons to sound stimuli were simultaneously recorded with a 16-channel electrode probe introduced into the IC. Click-evoked middle latency responses (MLR) recorded from the AC were suppressed for several hours after TTX injection. During AC inactivation the firing rate of IC neurons increased (40 % of neurons), decreased (44 %) or did not change (16 %) in comparison with control conditions. In several IC neurons, TTX injection resulted in alterations in the shape of the rate-level functions. Response thresholds, tuning properties and the type of discharge pattern of IC neurons were not altered during AC inactivation. However, in one-third of the neurons, the initial part of the response was less altered than the later, sustained part. In two-thirds of neuronal pairs, functional decortication resulted in a change in the cross-correlation coefficient. The results reveal the complex changes that appear in IC neuronal activity after functional ablation of the ipsilateral auditory cortex., J. Popelář, F. C. Nwabueze-Ogbo, J. Syka., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2003 Volume:52 | Number:5

Harvested from:

CDK

Metadata only:

false