Have main types of primary aldosteronism different phenotype?

Title:

Have main types of primary aldosteronism different phenotype?

Creator:

Z. Šomlóová, Indra, T., Jan Rosa, Ondřej Petrák, Branislav Štrauch, Tomáš Zelinka, Robert Holaj, and Jiří Widimský

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:46a35a40-4a13-4dc2-9c38-55afda183341
uuid:46a35a40-4a13-4dc2-9c38-55afda183341

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, primary aldosteronism, aldosterone producing adenoma, idiopathic hyperaldosteronism, pulse wave velocity, metabolic profile, 14, and 612

Type:

article, články, model:article, and TEXT

Description:

Primary aldosteronism (PA) is the most common cause of endocrine hypertension with a high frequency of cardiovascular complications. We found in our previous study higher occurrence of metabolic disturbances in patients with idiopathic hyperaldosteronism (IHA) compared to subjects with aldosterone-producing adenoma (APA). The aim of our present study is to evaluate potential differences in the frequency of endorgan damage (arterial stiffness and microalbuminuria) between two main types of PA. The diagnosis of the particular form of PA was based on adrenal venous sampling and/or histopathological examination. We analyzed clinical and laboratory data from 72 patients with PA (36 with IHA, 36 with APA). The arterial stiffness was expressed as the carotid-femoral pulse wave velocity (PWV) and the renal damage as urinary albumin excretion levels (UAE). Patients with IHA had significantly (p<0.03) higher prevalence of metabolic syndrome (17 % in APA, 35 % in IHA), higher triglycerides (1.37±0.71 mmol/l in APA, 1.85±0.87 mmol/l in IHA), lower HDL cholesterol (1.25±0.28 mmol/l in APA, 1.06±0.25 mmol/l in IHA), higher PWV (7.91±1.61 m/s in APA, 8.99±1.77 m/s in IHA) and higher UAE (12.93±2.21 mg/l in APA, 28.09±6.66 mg/l in IHA). It seems that patients with IHA may have a slightly different phenotype compared to APA., Z. Šomlóová ... [et al.]., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2012 Volume:61 | Number:4

Harvested from:

CDK

Metadata only:

false